Dimeric Alix nucleates ESCRT-III CHMP4 polymerization
Nolwenn Miguet, Carlos Contreras‐Martel, Sourav Maity, Els Pardon, Stéphane Frémont, Pauline Machebœuf, Christine Chatellard, Jean‐Marie Bourhis, Jean-Philippe Kleman, Andréa Dessen, Rémy Sadoul, Christophe J. Chipot, Jan Steyaert, Wouter H. Roos, Arnaud Échard, Winfríed Weissenhorn
This study shows dimeric Alix nucleates CHMP4 polymerization, essential for ESCRT-III membrane remodeling, and demonstrates that dimerization is required for plasma membrane repair.
bioRxiv · May 24, 2026 · PreprintBiochemistry