Author

Jonathan C. Deutsch

Stanford MedicineORCID 0009-0006-0968-501XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Assay:fluorescence / live-cell microscopy· 1 Assay:proteomics· 1

Frequent Co-Authors

Brian K. KobilkaiD· 2 shared John JanetzkoiD· 2 shared Rabindra V. ShivnaraineiD· 2 shared Steven ChuiD· 2 shared Asuka InoueiD· 1 shared Charles M. SchroederiD· 1 shared Daniel HilgeriD· 1 shared Dirk H. SiepeiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBiophysics

Brian K. KobilkaORCID

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2 papers

Recent·Most cited

BiophysicsbioRxivPreprintJun 30, 2025

Ligand-dependent G protein dynamics underlying opioid signaling efficacy

Jonathan C. Deutsch, Daniel Hilger, John Janetzko…·Rabindra V. Shivnaraine

This study uses smFRET to show that opioid ligands modulate Gi protein conformational dynamics, with higher-efficacy agonists promoting open, low-nucleotide-affinity states.

2 citations

fluorescence / live-cell microscopyexperimental assay

𝕏 PostBluesky

BiophysicsbioRxivPreprintJun 6, 2025

Membrane phosphoinositides allosterically tune β-arrestin dynamics to facilitate GPCR core engagement

John Janetzko, Jonathan C. Deutsch, Yuqi Shi…·Rabindra V. Shivnaraine

This study reveals that membrane phosphoinositides allosterically regulate β-arrestin dynamics, enabling engagement with minimally phosphorylated GPCRs.

3 citations

proteomicsexperimental assay

𝕏 PostBluesky