Rabindra V. Shivnaraine

This study uses smFRET to show that opioid ligands modulate Gi protein conformational dynamics, with higher-efficacy agonists promoting open, low-nucleotide-affinity states.

This study reveals that membrane phosphoinositides allosterically regulate β-arrestin dynamics, enabling engagement with minimally phosphorylated GPCRs.

ADMET-AI, a Chemprop-RDKit graph neural network trained on 41 TDC datasets, has the best average leaderboard rank and scores one million molecules in 3.1 hours.