Daniel Hilger

This paper discovers NHAP, a fungal metabolite that selectively inhibits Gi-signaling, demonstrating functional blockade in cardiomyocytes without cytotoxicity.

The paper develops biosensors to study GPCR-Gustducin interactions and finds that some non-taste GPCRs suppress signaling by forming unproductive complexes that block alternative pathways.

The paper determines the cryo-EM structure of a full-length human β1-adrenergic receptor in complex with Gs, revealing structural insights into ICL3's role in G protein activation.

This study uses smFRET to show that opioid ligands modulate Gi protein conformational dynamics, with higher-efficacy agonists promoting open, low-nucleotide-affinity states.

The paper presents the cryo-EM structure of the human histamine H2 receptor complexed with Gs protein in lipid nanodiscs, revealing insights into ligand binding and G protein coupling mechanisms.