Xionglue Wang

The paper identifies a novel 6mA-binding protein from Vibrio cholerae that recognizes the G6mAG motif, differing from DpnI's G6mATC specificity.

The paper shows that Co2+ and Ni2+ activate coronavirus nsp15, while Zn2+ inhibits it, and explains the structural basis for this activity.

This study shows SARS-CoV-2 nsp15 preferentially cleaves AU-rich dsRNA via nicking, supporting its role in evading host dsRNA sensors by degrading viral replication intermediates.

The paper identifies a single mutation, S43Y, that reduces transcription termination and RNA-dependent RNA polymerase activity in T7 RNA polymerase.