Xiangqian Kong

This study constructs a cross-etiological HSC atlas to reveal HSC heterogeneity and spatiotemporal dynamics in liver injury, identifying a novel apoptosis-prone HSC subtype and a 531-gene fibrosis signature.

This paper identifies EZH1-dependent H3K27me1 as an adaptive chromatin barrier limiting DNMT inhibitor response in colorectal cancer and shows that dual EZH1/2 inhibition synergizes with DNMTi to enhance therapeutic efficacy.

This study shows UHRF1 ubiquitin ligase activity and DNMT1 ubiquitin reading activity are essential for maintaining low-density CpG methylation, and their disruption leads to hypomethylation and PMD formation in cancer.