Shusruto Rishik

This study identifies sex-dimorphic molecular responses to microglial depletion in aged mice, highlighting differences in transcriptional and proteomic changes between males and females.

The paper shows re-replication is a physiological mechanism in human stem cell differentiation, increasing gene copy numbers to meet protein demands during differentiation.

The paper investigates gene amplification dynamics during chondrogenic differentiation of human mesenchymal stem cells and finds that amplifications are transient and stage-specific, correlating with proteoglycan deposition patterns.

The paper identifies age-related miRNA deregulation patterns in aging rhesus macaques, highlighting tissue and sex-specific changes and cross-species conservation.

The paper shows human and bacterial cells use extracellular vesicles and RNA cargo for bidirectional communication, affecting each other's physiology and gene expression.

This study uses spatial transcriptomics to compare aging and infection effects across multiple organs in mice, identifying shared gene expression patterns in immune pathways.

The paper develops a model to predict mRNA stability based on microRNA expression data and applies it to design microRNA-responsive constructs with specific activity patterns across cell types.