Author

Sergio Manzano-Sanchez

German Cancer Research CenterORCID 0009-0006-5460-5824Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:chromatin & epigenetic regulation· 2 Organism:human· 2 Assay:spatial transcriptomics· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Christoph PlassiD· 2 shared Michael SchereriD· 2 shared Albert Fradera-SolaiD· 1 shared Albrecht StenzingeriD· 1 shared Alexander Schramm· 1 shared Andreas KienzleiD· 1 shared Angelika Beate RiemeriD· 1 shared Aurélie ErnstiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCancer Biology

Christoph PlassORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintJun 5, 2026

Loss of the Y chromosome drives epigenetic and transcriptomic plasticity in lung adenocarcinoma

Kathleen Schlüter, Mei-Ju May Chen, Gizem Altun…·Maria Llamazares Prada

This study shows that loss of the Y chromosome in lung adenocarcinoma causes epigenetic and transcriptomic changes that increase lineage plasticity and poor clinical outcomes.

DOI 10.64898/2026.06.02.729627

humanDNA methylation

𝕏 PostBluesky

Cancer BiologybioRxivPreprintJul 30, 2025

Integrative spatial and multi-omic profiling in bladder cancer links L1 retrotransposition to extrachromosomal DNA, genomic instability, and viral mimicry response

Sophia J. Pribus, Ivana Osredek, Jan Otoničar…·Aurélie Ernst

This study integrates spatial and multi-omic data from bladder cancer patients to show L1 retrotransposition drives genomic instability, ecDNA formation, and a viral mimicry response.

2 citations

humanscRNA-seq

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