Author

Jan Otoničar

German Cancer Research Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Research Focus:genome assembly· 1

Frequent Co-Authors

Aurélie ErnstiD· 2 shared Jan O. KorbeliD· 2 shared Alexandra Eliassaf· 1 shared Andreas KienzleiD· 1 shared Angelika Beate RiemeriD· 1 shared Batsheva KeremiD· 1 shared Christoph PlassiD· 1 shared Frauke Devens· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCancer Biology

Aurélie ErnstORCID

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2 papers

Recent·Most cited

Integrative spatial and multi-omic profiling in bladder cancer links L1 retrotransposition to extrachromosomal DNA, genomic instability, and viral mimicry response

Sophia J. Pribus, Ivana Osredek, Jan Otoničar, Milena Simovic-Lorenz, Michael Scherer, Sergio Manzano-Sanchez, Andreas Kienzle, Urja Parekh, Vladimı́r Beneš, Pooja Sant, Jan‐Philipp Mallm, Karsten Brand, Angelika Beate Riemer, Holger Sültmann, Christoph Plass, , Aurélie Ernst

This study integrates spatial and multi-omic data from bladder cancer patients to show L1 retrotransposition drives genomic instability, ecDNA formation, and a viral mimicry response.

bioRxiv · Jul 30, 2025 · PreprintCancer Biology

P53 deficiency triggers hypertranscription, inducing nucleotide insufficiency causing replication stress, and genomic instability

Wisam Zaatra, George Philippos, Petr Smirnov, Shira Milo, Jan Otoničar, Michelle Chan, Michal Harel, Frauke Devens, Tchelet Goldberg, Alexandra Eliassaf, Karen Grimes, Michal Irony‐Tur Sinai, Gianluca Sigismondo, Tamar Geiger, Jan O. Korbel, , Aurélie Ernst

This study shows that p53 deficiency causes hypertranscription and nucleotide insufficiency, leading to replication stress and genomic instability, including chromothripsis.

bioRxiv · Apr 17, 2025 · PreprintCancer Biology