Developmental BiologySciencePeer-reviewed
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A DNA Typewriter records the cell lineage history of a mouse, from zygote to late organogenesis
Qi Yu, Haedong Kim, Sophie Seidel…·Jay Shendure
A prime-editing recorder in one mouse embryo yields a dated, zygote-rooted lineage tree of 1.28M cells at E13.5, enabling clonal dominance, sibling-fate and cell-type coupling analyses.