NeurosciencebioRxivPreprint
Targeted degradation of pathogenic TDP-43 proteins in amyotrophic lateral sclerosis using the AUTOTAC platform
Daniel Youngjae Park, Hee Yeon Kim, Eun Hye Cho…·Yong Tae Kwon
This paper develops AUTOTAC degraders to target and degrade pathogenic TDP-43 aggregates in ALS, showing efficacy in mice and entering clinical trials.
3 citations