Hyperactivation of the AXL-ICD/SIRT2 axis by Amyloid-β impairs astrocytic autophagic flux and exacerbates neuroinflammation
Tai Young Kim, Mridula Bhalla, Uiyeol Park, Seung Jae Hyeon, In‐Young Hwang, Youngsuk Seo, Wongu Youn, Jin-A Lee, Jung-Hee Lee, Boyoung Lee, Hoon Ryu, Changjoon Justin Lee
This study identifies the AXL-ICD/SIRT2 axis as a mechanism by which amyloid-β impairs astrocytic autophagy and exacerbates neuroinflammation in Alzheimer's disease.
bioRxiv · Aug 31, 2026 · PreprintNeuroscience