Author

Iyappan Ramachandiran

Cleveland ClinicORCID 0000-0002-0271-5478Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

Anthony J. HorakiD· 2 shared Daniela S. AllendeiD· 2 shared Rakhee BanerjeeiD· 2 shared Robert Nathaniel HelsleyiD· 2 shared Srinivasan DasarathyiD· 2 shared Venkateshwari VaradharajaniD· 2 shared William J. MasseyiD· 2 shared Adam E. MullickiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

Anthony J. HorakORCID

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2 papers

Recent·Most cited

The Lipid Hydrolase ABHD6 is a Therapeutic Target in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)-Related Hepatocellular Carcinoma

Danny Orabi, William J. Massey, Kevin K. Fung, Venkateshwari Varadharajan, Iyappan Ramachandiran, Rakhee Banerjee, Daniel J. Silver, Lucas J. Osborn, Amanda L. Brown, Stephanie Marshall, Daniel Ferguson, Shijie Cao, Rebecca C. Schugar, Chelsea Finney, Chase K. A. Neumann, , J. Mark Brown

This study identifies ABHD6 as a therapeutic target in MASLD-related HCC by showing its role in lysosomal lipid remodeling and tumor progression.

bioRxiv · Jul 29, 2025 · PreprintCancer Biology

Membrane Bound O-Acyltransferase 7 (MBOAT7) Shapes Lysosomal Lipid Homeostasis and Function to Control Alcohol-Associated Liver Injury

Venkateshwari Varadharajan, Iyappan Ramachandiran, William J. Massey, Raghav Jain, Rakhee Banerjee, Anthony J. Horak, Megan R. McMullen, Emily Huang, Annette Bellar, Shuhui Wang Lorkowski, Kailash Gulshan, Robert Nathaniel Helsley, Isabella James, Vai Pathak, Jaividhya Dasarathy, , Jonathan Mark Brown

This study shows that MBOAT7 loss of function in hepatocytes causes ethanol-induced liver injury by disrupting lysosomal biogenesis and autophagic flux.

eLife · Dec 27, 2023Peer-reviewedMolecular Biology