Author

David W. Streem

Cleveland ClinicORCID 0000-0001-5804-7598Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:gene regulatory network inference· 1 Assay:Hi-C· 1 Organism:mouse· 1

Frequent Co-Authors

Annette BellariD· 3 shared Jaividhya Dasarathy· 3 shared Nicole WelchiD· 3 shared Srinivasan DasarathyiD· 3 shared Laura E. NagyiD· 2 shared Megan R. McMulleniD· 2 shared Vai PathakiD· 2 shared Adam KimiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersImmunology

Annette BellarORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

ImmunologyAlcoholism Clinical and Experimental ResearchPeer-reviewedJun 1, 2026

Urine proteomic profiling at admission reveals complement biomarkers linked to alcohol-associated liver disease.

Luan Gavião Prado, Ryan J. Musich, Moyinoluwa Taiwo…·Laura E. Nagy

The paper identifies complement biomarkers in urine linked to alcohol-associated liver disease and provides insights into liver-kidney crosstalk mechanisms.

1 citation

humanproteomics

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ImmunologybioRxivPreprintAug 7, 2024

Genome Restructuring around Innate Immune Genes in Monocytes in Alcohol-associated Hepatitis

Adam Kim, Megan R. McMullen, Annette Bellar…·Srinivasan Dasarathy

The paper uses Hi-C and scRNA-seq to analyze chromatin structure and gene expression in monocytes from alcohol-associated hepatitis patients, finding altered genome organization affecting immune gene expression.

2 citations

humanHi-C

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Molecular BiologyeLifePeer-reviewedDec 27, 2023

Membrane Bound O-Acyltransferase 7 (MBOAT7) Shapes Lysosomal Lipid Homeostasis and Function to Control Alcohol-Associated Liver Injury

Venkateshwari Varadharajan, Iyappan Ramachandiran, William J. Massey…·Jonathan Mark Brown

This study shows that MBOAT7 loss of function in hepatocytes causes ethanol-induced liver injury by disrupting lysosomal biogenesis and autophagic flux.

9 citations

mousestatistical model

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