Thomas Mulvaney

This study uses cryo-EM to reveal drebrin's structural interaction with F-actin through two domains, explaining its modulatory role in actin networks and competitive binding with other proteins.

ChemEM docks small molecules into medium-resolution cryo-EM maps using difference maps and a scoring function, outperforming existing methods and demonstrating utility at low resolutions.

The paper evaluates CASP15 cryoEM predictions using density maps, showing high accuracy but challenges in side-chain positioning and loop modeling.

PICKLUSTER identifies sub-interfaces in protein-protein complexes using distance clustering to improve targeting of large interfaces.