Claire Chevalier

This study investigates the effects of prenatal DYRK1A inhibition with Leucettine L41 in DS mouse models, showing lasting cognitive and gene expression improvements with model-specific outcomes.

This study evaluates the efficacy of 5IA in the Dp(16)1Yey mouse model of Down syndrome, finding improved motor coordination but no cognitive rescue, suggesting divergent pathophysiology compared to Ts65Dn models.

This study identifies Ripply3 overdosage as a cause of mid-face shortening in Down syndrome models through Tbx1 downregulation during branchial arch development.

The paper introduces a new mouse model, Ts66Yah, for Down syndrome that replicates DS cognitive features and reveals genetic interactions between triplicated regions homologous to Hsa21 and unrelated regions.

This paper shows that BIN1 overexpression in mice leads to early structural and functional impairments in hippocampal pathways associated with Alzheimer's disease, independent of A-beta changes.

The paper identifies six biological cascades involving key genes that alter behaviour and cognition in Down syndrome mouse models.

The paper investigates the oligogenic effects of 16p11.2 copy number variation on craniofacial development across species, showing that individual genes and their combinations influence facial structure.