Arnaud Duchon

This study investigates the effects of prenatal DYRK1A inhibition with Leucettine L41 in DS mouse models, showing lasting cognitive and gene expression improvements with model-specific outcomes.

This study shows that increased DYRK1A levels specifically impair presynaptic long-term potentiation in a mouse model, suggesting a role in memory precision.

This study characterizes the Ts66Yah murine model of Down syndrome, revealing genotype-related molecular changes in hippocampal pathways linked to aging and cognitive decline.

This study shows that AUTS2 gene dosage affects synaptic AMPA receptors through the AUTS2-TTC3-AKT-mTORC1 pathway, leading to behavioral and cognitive impairments in mice.

The paper introduces a new mouse model, Ts66Yah, for Down syndrome that replicates DS cognitive features and reveals genetic interactions between triplicated regions homologous to Hsa21 and unrelated regions.

The paper identifies six biological cascades involving key genes that alter behaviour and cognition in Down syndrome mouse models.

This study shows pioglitazone reduces excessive diacylglycerol signaling in Fmr1-KO mice, improving behavioral deficits associated with Fragile X syndrome.