AUTS2 gene dosage affects synaptic AMPA receptors via a local dendritic spine AUTS2-TTC3-AKT-mTORC1 signaling dysfunction
Aude-Marie Lepagnol-Bestel, Arnaud Duchon, Julia Viard, Mirna Kvajo, Rachel Daudin, Malik Khelfaoui, Simon Haziza, Yann Loe-Mie, Mattia Aime, Futoshi Suizu, Marie‐Christine Birling, Mounia Bensaid, Sylvie Jacquot, Pascale Koebel, Céline Reverdy, , Michel Simonneau
This study shows that AUTS2 gene dosage affects synaptic AMPA receptors through the AUTS2-TTC3-AKT-mTORC1 pathway, leading to behavioral and cognitive impairments in mice.
bioRxiv · Dec 1, 2022 · PreprintNeuroscience