Author

Mariana Zarate-Mendez

University of CambridgeORCID 0009-0006-8224-5088Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1 Research Focus:spatial domain detection· 1

Frequent Co-Authors

Denisa HathaziiD· 2 shared Oliver PodmanickyiD· 2 shared Rita HorváthiD· 2 shared András LakatosiD· 1 shared Camilla LyonsiD· 1 shared Daniel LagosiD· 1 shared Éva MoravaiD· 1 shared Evan ReidiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersNeuroscience

Denisa HathaziORCID

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2 papers

Recent·Most cited

NeuroscienceDOAJ (DOAJ: Directory of Open Access Journals)Peer-reviewedJun 21, 2026

Mitochondrial DNA heteroplasmy drives cortical neuronal disturbances in human organoids harbouring the common m.3243A>G mutation

Denisa Hathazi, Camilla Lyons, Daniel Lagos…·Rita Horváth

This study shows that high mitochondrial DNA heteroplasmy in human organoids with the m.3243A>G mutation causes cortical neuronal disturbances, including axonal degeneration and apoptosis, similar to MELAS patients.

DOI 10.1038/s41467-026-74103-y

humanbulk RNA-seq

𝕏 PostBluesky

NeurosciencebioRxivPreprintDec 31, 2025

Cell-type-specific adaptations to mitochondrial stress underly the neurological presentations of MTRFR mutations

Mariana Zarate-Mendez, Kaela O’Connor, Natalia Malig…·Rita Horváth

This study identifies cell-type-specific adaptations to mitochondrial stress in MTRFR mutations, showing cortical neurons activate survival programs while motor neurons undergo apoptosis.

DOI 10.64898/2025.12.30.696998

humanbulk RNA-seq

𝕏 PostBluesky