Mostafa Zedan

The paper introduces in-cell LiP-MS to study protein structural changes and biomolecular condensates in live human cells, revealing structural alterations under stress and validating them with microscopy.

The paper shows that during acute glucose withdrawal in yeast, newly synthesized stress mRNAs escape translational repression while pre-existing mRNAs are repressed, revealing a timing-based coordination of transcriptional and translational responses.

The paper investigates the distinct physiological roles of NatA and NatB in S. cerevisiae through transcriptome, translatome, and proteome profiling of mutants, revealing specific effects on gene expression and protein folding.