Molecular BiologyMolecular Systems BiologyPeer-reviewed
Paradoxical non-catalytic kinase functions are driven by inhibitor-induced displacement of autoinhibitory domains
Viviane Reber, Sabrina Keller, Stefanie A. Loosli…·Matthias Gstaiger
The paper identifies inhibitor-induced structural changes in kinases that drive non-catalytic effects, revealing the ATP-binding site as a key regulator of kinase conformation and interactions.
DOI 10.1038/s44320-026-00229-2