Tatjana Kleele

The paper identifies miR-1229-3p as a human-specific microRNA that delays neuronal synaptogenesis by reducing mitochondrial metabolism.

The paper identifies inhibitor-induced structural changes in kinases that drive non-catalytic effects, revealing the ATP-binding site as a key regulator of kinase conformation and interactions.

The paper investigates asymmetric mitochondrial trafficking in cultured cells, showing it maintains mitochondrial network morphology by balancing perinuclear biogenesis.

The paper introduces in-cell LiP-MS to study protein structural changes and biomolecular condensates in live human cells, revealing structural alterations under stress and validating them with microscopy.

The paper identifies a retrograde transit filter in distal axons mediated by optineurin that regulates mitochondrial homeostasis, independent of PINK1 and parkin.