Paradoxical non-catalytic kinase functions are driven by inhibitor-induced displacement of autoinhibitory domains
Viviane Reber, Sabrina Keller, Stefanie A. Loosli, Yumi Arima, Tatjana Kleele, Paola Picotti, Matthias Gstaiger
The paper identifies inhibitor-induced structural changes in kinases that drive non-catalytic effects, revealing the ATP-binding site as a key regulator of kinase conformation and interactions.
Molecular Systems Biology · Jul 2, 2026Peer-reviewedMolecular Biology