Author

Sabrina Keller

ETH ZurichORCID 0000-0002-8976-9208Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1 Molecular Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:proteomics· 3 Research Focus:cell-cell communication· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Matthias GstaigeriD· 4 shared Paola PicottiiD· 3 shared Viviane ReberiD· 3 shared Adriano AguzziiD· 1 shared Ana CorrioneroiD· 1 shared Andreas KrämeriD· 1 shared Benedict‐Tilman BergeriD· 1 shared C.H. ArrowsmithiD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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4 shared papersCell Biology

Matthias GstaigerORCID

Mutual co-authors in cluster

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4 papers

Recent·Most cited

Chemically induced USP21-KLHL12 association recruits USP21 to COPII assembly

Victoria Vu, Michael Kanaris, Esther Wolf, Sabrina Keller, Qi Liu, Conrad Veranso Simoben, Shabbir Ahmad, Viviane Reber, Magdalena M. Szewczyk, Peter Loppnau, Matthew E. R. Maitland, Ella C. Adamson, Paola Picotti, Derek Wilson, C.H. Arrowsmith, , Dalia Baršytė-Lovejoy

The paper shows that BAY-805 induces USP21-KLHL12 association, recruiting USP21 to COPII vesicles and impairing large cargo transport.

bioRxiv · Sep 17, 2026 · PreprintCell Biology

Paradoxical non-catalytic kinase functions are driven by inhibitor-induced displacement of autoinhibitory domains

Viviane Reber, Sabrina Keller, Stefanie A. Loosli, Yumi Arima, Tatjana Kleele, Paola Picotti, Matthias Gstaiger

The paper identifies inhibitor-induced structural changes in kinases that drive non-catalytic effects, revealing the ATP-binding site as a key regulator of kinase conformation and interactions.

Molecular Systems Biology · Jul 2, 2026Peer-reviewedMolecular Biology

Structure-function relationship of alpha-synuclein fibrillar polymorphs derived from distinct synucleinopathies

Tetiana Serdiuk, Virginie Redeker, Jimmy Savistchenko, Sandesh Neupane, Walther Haenseler, Yanick Fleischmann, Viviane Reber, Sabrina Keller, Cinzia Tiberi, Ruxandra Bachmann-Gagescu, Matthias Gstaiger, Thomas Braun, Roland Riek, Steve Gentleman, Adriano Aguzzi, , Paola Picotti

This study identifies structural and functional differences in alpha-synuclein fibrils from Parkinson's disease, Dementia with Lewy Bodies, and Multiple System Atrophy, linking these differences to disease-specific cellular responses and potential therapeutic targets.

Molecular Systems Biology · Mar 11, 2026Peer-reviewedSystems Biology

Covalent targeting leads to the development of LIMK1 isoform-selective inhibitors

Sebastian Mandel, Thomas Hanke, Niall Prendiville, María Baena-Nuevo, Lena M. Berger, Frederic Farges, Martin P. Schwalm, Benedict‐Tilman Berger, Andreas Krämer, Lewis Elson, Hayuningbudi Saraswati, Kamal Rayees Abdul Azeez, Verena Dederer, Sebastian Mathea, Ana Corrionero, , Stefan Knapp

This study develops a covalent LIMK1 inhibitor that selectively targets a unique cysteine, enabling isoform-specific studies of LIMK1 function.

Journal of Medicinal Chemistry · Jul 2, 2025Peer-reviewedBiochemistry