The paper examines how polygenic indices for educational attainment change across birth cohorts and regions in Germany, finding stronger associations in recent cohorts and the East but weaker effects for women.

bioRxiv · Sep 21, 2026 · PreprintGenomics

Developmental Correlates of Epigenetic and Polygenic Indices of Cognition and Educational Attainment from Birth to Young Adulthood

Deniz Fraemke, Lena Paulus, Isabel K. Schuurmans, J. Walter, Darina Czamara, Alicia M. Schowe, Abby J. deSteiguer, Peter T. Tanksley, Aysu Okbay, Bastian Mönkediek, Jana Instinske, M. M. Nöthen, Charlotte K. L. Disselkamp, Andreas J. Forstner, E. Binder, , L. Raffington

The paper examines developmental correlates of epigenetic and polygenic indices of cognition and education from birth to young adulthood, finding Epigenetic-g is plastic in early childhood and captures distinct variation from polygenic indices.

bioRxiv · Apr 3, 2026 · PreprintGenomics

Linked emergence of racial disparities in mental health and epigenetic biological aging across childhood and adolescence

M. Aikins, Yayouk Eva Willems, Deniz Fraemke, Colter M. Mitchell, Bridget J. Goosby, Laurel Raffington

The paper examines the link between racial disparities in mental health and epigenetic biological aging across childhood and adolescence using a birth cohort study.

Molecular Psychiatry · Apr 9, 2025Peer-reviewedGenomics

Differences in polygenic associations with educational attainment between West and East Germany before and after reunification

Deniz Fraemke, Yayouk Eva Willems, Aysu Okbay, Gert G. Wagner, Elliot M. Tucker–Drob, K. Paige Harden, Ralph Hertwig, Philipp Koellinger, Laurel Raffington

The paper finds stronger polygenic associations with educational attainment in East Germans after reunification compared to West Germans.

bioRxiv · Mar 21, 2024 · PreprintGenetics