The paper examines developmental correlates of epigenetic and polygenic indices of cognition and education from birth to young adulthood, finding Epigenetic-g is plastic in early childhood and captures distinct variation from polygenic indices.

bioRxiv · Apr 3, 2026 · PreprintGenomics

Genomic insights into substance use and disinhibitory disorders

Camille Michèle Williams, Holly E. Poore, Diego Londoño-Correa, Yuchen Ning, Natasia S. Courchesne‐Krak, Maia Choi, Justin D. Tubbs, Matthew Rosenblatt, Peter T. Tanksley, Fazil Alıev, Nathaniel Y. Bell, Joseph D. Deak, Jean Gonzalez, Mariela V. Jennings, Emma C. Johnson, , Travis T. Mallard

This study identifies 1,294 genomic regions and 961 effector genes associated with externalizing disorders, revealing neural mechanisms and polygenic predictors of variance in these conditions.

medRxiv · Feb 9, 2026 · PreprintGenetic & Genomic Medicine

Robust inference and widespread genetic correlates from a large-scale genetic association study of human personality

Ted Schwaba, Margaret L. Clapp Sullivan, Wonuola A. Akingbuwa, Kerli Ilves, Peter T. Tanksley, Camille Michèle Williams, Yavor Dragostinov, Wangjingyi Liao, Lindsay S. Ackerman, Josephine C. M. Fealy, Gibran Hemani, Javier de la Fuente, Priya Gupta, Murray B. Stein, Joel E. Gelernter, , Aino I. L. Saarinen

This study identifies 1,257 genetic variants associated with human personality traits using large-scale GWAS and finds widespread genetic correlations with behaviors and life outcomes.

bioRxiv · May 16, 2025 · PreprintGenomics

Stability of DNA-Methylation Profiles of Biological Aging in Children and Adolescents

Abby J. deSteiguer, Laurel Raffington, Aditi Sabhlok, Peter T. Tanksley, Elliot M. Tucker–Drob, K. Paige Harden

This study examines the stability of DNA-methylation profiles of biological aging in children and adolescents over four years, finding moderate stability and less stability compared to adults.

bioRxiv · Oct 30, 2023 · PreprintDevelopmental Biology

Guidelines for Evaluating the Comparability of Down-Sampled GWAS Summary Statistics

Camille Michèle Williams, Holly E. Poore, Peter T. Tanksley, Hyeokmoon Kweon, Natasia S. Courchesne‐Krak, Diego Londoño-Correa, Travis T. Mallard, Peter B. Barr, Philipp Koellinger, Irwin D. Waldman, Sandra Sanchez‐Roige, K. Paige Harden, Abraham A. Palmer, Danielle M. Dick, Richard Karlsson Linnér

This paper evaluates how down-sampling affects GWAS summary statistics and recommends reporting specific analyses to support their use.

Behavior Genetics · Sep 15, 2023Peer-reviewedGenetics

Socially stratified epigenetic profiles are associated with cognitive functioning in children and adolescents

Laurel Raffington, Peter T. Tanksley, Aditi Sabhlok, Liza Vinnik, Travis T. Mallard, Lucy S. King, Bridget J. Goosby, K. Paige Harden, Elliot M. Tucker–Drob

The paper examines DNA-methylation profiles in children and adolescents, finding associations between social inequality and epigenetic markers of inflammation, cognitive functioning, and biological aging.

Psychological Science · Dec 2, 2022Peer-reviewedGenetics