Author

Sigrid K. Fey

Cancer Research UK Scotland InstituteORCID 0009-0007-3667-513XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:mouse· 2

Frequent Co-Authors

Andrew D. CampbelliD· 2 shared Arafath Kaja NajumudeeniD· 2 shared Catriona A. FordiD· 2 shared Colin NixoniD· 2 shared Jennifer P. MortoniD· 2 shared Kathryn L. GilroyiD· 2 shared Laura M. MillettiD· 2 shared Owen James SansomiD· 2 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

Andrew D. CampbellORCID

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2 papers

Recent·Most cited

Cancer BiologyCancer ResearchPeer-reviewedOct 16, 2024

Kras loss of heterozygosity promotes MAPK dependent pancreatic ductal adenocarcinoma and induces therapeutic sensitivity

Sigrid K. Fey, Arafath Kaja Najumudeen, Dale M. Watt…·Owen James Sansom

This study shows that loss of wild-type Kras enhances oncogenic Kras signaling and promotes pancreatic ductal adenocarcinoma, while also increasing sensitivity to MEK1/2 inhibitors.

12 citations

mouseexperimental assay

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Cancer BiologyNature CommunicationsPeer-reviewedJan 2, 2024

KRAS allelic imbalance drives tumour initiation yet suppresses metastasis in colorectal cancer in vivo

Arafath Kaja Najumudeen, Sigrid K. Fey, Laura M. Millett…·Owen James Sansom

This study shows that wild-type KRAS suppresses tumour growth and metastasis in KRAS mutant colorectal cancer while enhancing resistance to MEK inhibition.

27 citations

mouseexperimental assay

𝕏 PostBluesky