Kathryn L. Gilroy

This study shows that Runx1 and Runx2 suppress Wnt/β-catenin-driven mammary tumourigenesis, with combined loss leading to increased tumour development and oncogenic pathway activation.

This study shows that WNT signaling enhances NF-κB activation and drug resistance in KRAS-mutant colorectal cancer, suggesting a therapeutic strategy targeting WNT and MEK pathways.

This study shows that inactivating HIRA during embryonic development affects melanoblasts and leads to aging-related defects in melanocyte stem cells, but not in postnatal melanocytes.

This study identifies a druggable PREX2/RAC1/PI3Kβ signalling axis in BRAF-mutant melanoma that confers resistance to therapies and can be targeted to improve treatment outcomes.

The paper identifies two neutrophil subtypes in cancer using single-cell RNA sequencing, showing their conservation across species and tumor types, and links them to immunosuppressive pathways.

MouSR is an open-source tool for rapid transcriptomic analysis of human or mouse data, enabling biological discovery without programming expertise.