Sutichot D. Nimkulrat

The paper identifies cell type-specific and sex-specific transcriptional dysregulation in islets of Langerhans in Down syndrome mice, linking it to increased T2D risk.

The paper tests two models of beta cell dedifferentiation in diabetes using lineage tracing and RNA-seq in mice, showing dedifferentiation is not a reversal of development but varies by diabetes type.

This study shows that loss of Robo1 and Robo2 in beta cells disrupts synchronized calcium oscillations in islets of Langerhans in vivo, indicating that islet architecture is essential for this coordination.