Michael Raymond Whittaker

This paper synthesizes and evaluates cationic lipid-terminated oligomers (CLOs) with potent and selective antibacterial activity against priority pathogens, showing low toxicity and tunable properties.

This study shows that targeting mGlu5 in endosomes improves analgesia by inhibiting nuclear ERK1/2 signaling and reducing neuronal excitability in pain models.

This study uses metabolomics to analyze how two CLOs disrupt MRSA membranes, revealing distinct metabolic changes that indicate membrane destabilization and lipid remodeling.

This study uses metabolomics to reveal that C12-o-(BG-D)-10 disrupts bacterial membrane organization and multiple metabolic pathways, contributing to its antimicrobial activity against MRSA.