Stavroula Tsitkanou

This study shows mitochondrial-targeted plastoquinone SkQ1 reduces early muscle weakness in ovarian cancer mice by improving calcium handling and mitochondrial function, without preventing atrophy.

The paper isolates and analyzes the proteome of TDP-43-associated insoluble stress granules in an ALS mouse model, identifying sustained stress granule formation, CLUH granule recruitment, and impaired mitochondrial metabolism.