Author

Cecilia Perrucci

National Research CouncilORCID 0009-0007-4514-2781Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Assay:multiome· 1 Assay:protein sequence· 1

Frequent Co-Authors

Fabio LauriaiD· 3 shared Gabriella VieroiD· 3 shared Manuela BassoiD· 3 shared Elena PerenthaleriD· 2 shared Federica ManiscalcoiD· 2 shared Gabriele TomèiD· 2 shared Ilaria BrunoiD· 2 shared Luisa DoniniiD· 2 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersMolecular Biology

Fabio LauriaORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Molecular BiologybioRxivPreprintOct 17, 2025

Empowering multiplexed ultra-throughout ribosome profiling with RiboWich

Ilaria Bruno, Cecilia Perrucci, Gabriele Tomè…·Gabriella Viero

RiboWich improves ribosome profiling by eliminating ribosome purification and enabling high-throughput, low-input translatome analysis.

1 citation

Ribo-seqexperimental assay

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Molecular BiologybioRxivPreprintJun 3, 2025

Translation-specific disruption of Col1a1 expression in multiple models of Spinal Muscular Atrophy can be rescued by Risdiplam.

Gaurav Sharma, Martina Paganin, Yu-Ting Huang…·Gabriella Viero

The paper identifies COL1A1 as a translation-specific biomarker of SMA severity and shows it can be rescued by SMN-restoring therapies in multiple models.

DOI 10.1101/2025.06.03.657600

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Molecular BiologybioRxivPreprintMay 15, 2025

Disruption of ribosome dynamics and mRNA homeostasis triggers a cascading imbalance in protein synthesis in models of Amyotrophic Lateral Sclerosis

Fabio Lauria, Federica Maniscalco, Cecilia Perrucci…·Gabriella Viero

This study investigates how TDP-43 dysregulation disrupts protein synthesis in ALS models by altering ribosome dynamics and mRNA homeostasis, revealing a conserved mechanism across in vitro and in vivo systems.

DOI 10.1101/2025.05.15.654227

humanproteomics

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