Author

Federica Maniscalco

University of TrentoORCID 0000-0002-9757-6043Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:differential expression· 2 Assay:protein sequence· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1

Frequent Co-Authors

Fabio LauriaiD· 3 shared Gabriella VieroiD· 3 shared Alessandro QuattroneiD· 2 shared Cecilia PerrucciiD· 2 shared Deborah DonzeliD· 2 shared Elena PerenthaleriD· 2 shared Ewout J. N. GroeniD· 2 shared Manuela BassoiD· 2 shared

Activity by Year

2020-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersMolecular Biology

Fabio LauriaORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Translation-specific disruption of Col1a1 expression in multiple models of Spinal Muscular Atrophy can be rescued by Risdiplam.

Gaurav Sharma, Martina Paganin, Yu-Ting Huang, Elena Perenthaler, Ilaria Signoria, Kiterie M. E. Faller, Federica Maniscalco, Cecilia Perrucci, Deborah Donzel, Helena Chaytow, Manuela Basso, Fabio Lauria, Rashmi Kothary, W. Ludo van der Pol, Peter Claus, , Gabriella Viero

The paper identifies COL1A1 as a translation-specific biomarker of SMA severity and shows it can be rescued by SMN-restoring therapies in multiple models.

bioRxiv · Jun 3, 2025 · PreprintMolecular Biology

Disruption of ribosome dynamics and mRNA homeostasis triggers a cascading imbalance in protein synthesis in models of Amyotrophic Lateral Sclerosis

Fabio Lauria, Federica Maniscalco, Cecilia Perrucci, Marta Marchioretto, Ilaria Bruno, Gabriele Tomè, Federica Cella, Emma Busarello, Martina Sevegnani, Lorenzo Lunelli, Luisa Donini, Toma Tebaldi, Michael H. Antoni, Daniele Pollini, Daniele Peroni, , Gabriella Viero

This study investigates how TDP-43 dysregulation disrupts protein synthesis in ALS models by altering ribosome dynamics and mRNA homeostasis, revealing a conserved mechanism across in vitro and in vivo systems.

bioRxiv · May 15, 2025 · PreprintMolecular Biology

SMN-primed ribosomes modulate the translation of transcripts related to Spinal Muscular Atrophy

Fabio Lauria, Paola Bernabò, Toma Tebaldi, Ewout J. N. Groen, Elena Perenthaler, Federica Maniscalco, Annalisa Rossi, Deborah Donzel, Massimiliano Clamer, Marta Marchioretto, Neža Omersa, Julia Orri, Mauro Dalla Serra, Gregor Anderluh, Alessandro Quattrone, , Gabriella Viero

The paper shows SMN protein binds ribosomes and modulates translation of specific mRNAs in SMA, causing translational defects in motor neuron-related proteins.

Nature Cell Biology · Sep 21, 2020Peer-reviewedNeuroscience