Author
John D. Gross
University of California, San FranciscoORCID 0000-0002-1377-4705Unclaimed ORCID profile · follow to get notified of new preprints
Additional preprints under this name without ORCID
Biology Disciplines
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2018-2026 · peak 4/yrCo-Author Collaboration Network
10 top collaborators · 8 mutual co-author links5 papers
Recent·Most cited
- BiochemistryNucleic Acids ResearchPeer-reviewed
Deadenylation and Decapping Factors Cooperatively Stimulate Biochemical Activities of DEAD-Box ATPase Dhh1
Gabriel A. Braun, Rakesh Kumar, Alan G. Hinnebusch, John D. Gross
This study shows that Dhh1's ATPase activity is cooperatively enhanced by deadenylation and decapping factors through distinct mechanisms.
DOI 10.1093/nar/gkag908 - Molecular BiologyCell ReportsPeer-reviewed
Structure of the E3 ligase CRL2-ZYG11B with substrates reveals the molecular basis for N-degron recognition and ubiquitination
Xi Liu, Li Yuping, Lennice K. Castro…·John D. Gross
The paper presents Cryo-EM structures of the CRL2-ZYG11B complex with substrates, revealing how ZYG11B recognizes and ubiquitinates Gly/N-degrons to activate the NLRP1 inflammasome.
1 citation - BiochemistrybioRxivPreprint
Sequence-encoded autoinhibition couples mRNA decapping activity to phase separation
Trase Aguigam, Katarzyna Grab, Joanna Kowalska…·John D. Gross
The paper identifies sequence-encoded autoinhibition in fission yeast Dcp2 that regulates mRNA decapping activity and shows how conformational relief is propagated within phase-separated condensates.
DOI 10.64898/2026.06.16.732745 - BiochemistrybioRxiv
Control of mRNA decapping by autoinhibition
David R Paquette, Ryan W Tibble, Tristan S Daifuku, John D Gross
The paper investigates how the Dcp1:Dcp2 complex is autoinhibited by its disordered C-terminus and how Edc1 and Edc3 activate decapping through distinct mechanisms.
DOI 10.1093/nar/gky233