BiophysicsbioRxivPreprint
Chaperonin recognition of protein dynamics drives drug resistance
Junlang Liu, Zhihui Qi, João V. Rodrigues…·Eugene I. Shakhnovich
The paper shows that chaperonin GroEL/S promotes drug resistance by recognizing protein dynamics, displacing inhibitors and restoring active enzyme function.
DOI 10.64898/2026.06.03.729952