Chaperonin recognition of protein dynamics drives drug resistance
Junlang Liu, Zhihui Qi, João V. Rodrigues, Z X Zhang, Qianxiang Xu, Abhinav Dubey, Harrison K. Wang, Dongtao Cui, Zeyang Li, Fatima Aly, Doeke R. Hekstra, Eugene I. Shakhnovich
The paper shows that chaperonin GroEL/S promotes drug resistance by recognizing protein dynamics, displacing inhibitors and restoring active enzyme function.
bioRxiv · Jun 7, 2026 · PreprintBiophysics