Author

Ayuna Tsutsumi

Kyoto UniversityORCID 0009-0007-5903-006XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:electrophysiology· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

Haruo OgawaiD· 2 shared Hiroyuki KagechikaiD· 2 shared Nagomi KurebayashiiD· 2 shared Ryosuke IshidaiD· 2 shared Takashi MurayamaiD· 2 shared Takashi SakuraiiD· 2 shared Yuya OtoriiD· 2 shared Eri Nakashima· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiochemistry

Haruo OgawaORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintMay 23, 2026

Structural basis for Ca2+-dependent allosteric modulation of cardiac ryanodine receptor by Ryanozole

Yuya Otori, Takashi Murayama, Ayuna Tsutsumi…·Haruo Ogawa

This study defines the mechanism of Ryanozole's Ca2+-dependent modulation of RyR2 using cryo-EM, mutagenesis, and functional assays, revealing its structural basis for CPVT therapy.

DOI 10.64898/2026.05.11.724262

humanstructural biology

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Pharmacology & ToxicologyBritish Journal of PharmacologyPeer-reviewedApr 27, 2026

A novel RyR2-selective stabilizer prevents stress-induced ventricular arrhythmias without impairing cardiac function

Nagomi Kurebayashi, Masami Kodama, Hana Inoue…·Takashi Sakurai

Ryanozole, a RyR2-selective stabilizer, prevents stress-induced arrhythmias without impairing cardiac function in CPVT mouse models.

1 citation

mouseelectrophysiology

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