Author

Hiroyuki Kagechika

Laboratory for Biomaterials and Bioengineering, Institute of Integrated Research, Institute of Science TokyoORCID 0000-0002-6747-1013Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:electrophysiology· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

Ayuna TsutsumiiD· 2 shared Haruo OgawaiD· 2 shared Nagomi KurebayashiiD· 2 shared Ryosuke IshidaiD· 2 shared Takashi MurayamaiD· 2 shared Takashi SakuraiiD· 2 shared Yuya OtoriiD· 2 shared Eri Nakashima· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiochemistry

Ayuna TsutsumiORCID

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2 papers

Recent·Most cited

Structural basis for Ca2+-dependent allosteric modulation of cardiac ryanodine receptor by Ryanozole

Yuya Otori, Takashi Murayama, Ayuna Tsutsumi, Ryosuke Ishida, Sho Takeuchi, Raymond N. Burton‐Smith, Kazuyoshi Murata, Takashi Sakurai, Hiroyuki Kagechika, Nagomi Kurebayashi, Haruo Ogawa

This study defines the mechanism of Ryanozole's Ca2+-dependent modulation of RyR2 using cryo-EM, mutagenesis, and functional assays, revealing its structural basis for CPVT therapy.

bioRxiv · May 23, 2026 · PreprintBiochemistry

A novel RyR2-selective stabilizer prevents stress-induced ventricular arrhythmias without impairing cardiac function

Nagomi Kurebayashi, Masami Kodama, Hana Inoue, Masato Konishi, Masami Sugihara, Takashi Murayama, Ryosuke Ishida, Koichiro Ishii, Shuichi Mori, Yukari Endo, Xi Zeng, Yukiko Inoue, Takayoshi Inoue, S. Noguchi, Hajime Nishio, , Takashi Sakurai

Ryanozole, a RyR2-selective stabilizer, prevents stress-induced arrhythmias without impairing cardiac function in CPVT mouse models.

British Journal of Pharmacology · Apr 27, 2026Peer-reviewedPharmacology & Toxicology