Liangfu Chen

Epiregulon infers single-cell TF activity using ATAC-seq and RNA-seq to predict drug response and identify drivers of cell state.

This paper introduces TRACK-IT, a live imaging technique that reveals rapid, cohesin-dependent genomic motion across multiple scales, challenging previous assumptions about genome organization.

The paper shows that enhancer-promoter communication scales with genomic distance in a gene-specific manner, independent of 3D contact frequency or chromatin state.

The paper investigates how structural elements regulate SOX9 expression over long genomic distances in PRS patients by analyzing chromatin topology and modeling interactions.

The paper develops BayFish, a Bayesian inference method to estimate kinetic parameters of gene expression from smFISH data, showing increased promoter transition rates in response to stimuli.