Andrew J. Spakowitz

This study develops a tunable DCC hydrogel platform to control viscoelastic properties for 3D human tissue modeling.

This study shows that macromolecular crowding promotes DNA writhe under tension by inducing a contractile force dependent on crowder concentration and molecular weight.

The paper uses polymer mechanics and nucleosome positioning to explain genomic contacts, finding that nucleosomes explain 71% of close contacts within 500 kb.

This paper introduces TRACK-IT, a live imaging technique that reveals rapid, cohesin-dependent genomic motion across multiple scales, challenging previous assumptions about genome organization.

This paper develops a modeling framework to interpret RICC-seq data by simulating oligonucleosome structures and extracting nucleosome repeat lengths using a convolutional neural network.

The paper uses live imaging and modeling to show that random diffusion and a small number of linkages suffice for homolog pairing during meiosis in budding yeast.