Anne E. West

Epitope-tagged knockin mice show histone H1.4 protein accumulates in postmitotic neurons, shifts toward B-compartment heterochromatin with maturation, and H1f2/H1f4 loss impairs cerebellar granule neuron chromatin compaction.

The paper investigates transcriptional changes in VTA neurons after chronic cocaine cessation and their role in relapse, finding that BDNF transcription is causally linked to cocaine seeking.

This study investigates how Zic transcription factors regulate gene expression during cerebellar granule neuron maturation by analyzing their binding patterns and interactions with other transcription factors.

The paper identifies molecular features of GAD2+/VGLUT2+ neurons in the mouse lateral habenula using single-nucleus RNA sequencing, revealing sex-specific gene expression and links to depression.

This study shows that dynamic changes in H3K27me3 distribution regulate gene expression programs during cerebellar granule neuron maturation.

The paper identifies cell-type specific transcriptional changes in PV+ interneurons of the nucleus accumbens in response to amphetamine exposure and links these changes to addictive-like behaviors.

This paper describes the generation of two transgenic mouse lines for in vivo epigenome editing using CRISPR-based systems to activate or repress gene expression.

This study identifies a striatal interneuron circuit where parvalbumin-positive fast-spiking interneurons represent target distance and regulate striatal projection neuron activity to modulate movement velocity during pursuit behavior.

The paper develops BayFish, a Bayesian inference method to estimate kinetic parameters of gene expression from smFISH data, showing increased promoter transition rates in response to stimuli.