Author

Sofia Francia

Istituto di Genetica MolecolareORCID 0000-0002-4578-9442Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Cell Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 3 Organism:human· 3 Research Focus:cell-cell communication· 2 Assay:DNA methylation· 2 Organism:Drosophila· 2 Organism:C. elegans· 1

Frequent Co-Authors

Fabrizio d’Adda di FagagnaiD· 3 shared Adelaide Riccardi· 2 shared Alessio ColantoniiD· 2 shared Fabio IannelliiD· 2 shared Francesca EspositoiD· 2 shared Matteo CabriniiD· 2 shared Stefania ModafferiiD· 2 shared Ubaldo GioiaiD· 2 shared

Activity by Year

2018-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersMolecular Biology

Fabrizio d’Adda di FagagnaORCID

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4 papers

Recent·Most cited

Molecular BiologyCell ReportsPeer-reviewedDec 1, 2025

DROSHA, DICER and Damage-Induced long ncRNA control BMI1-dependent transcriptional repression at DNA double-strand break

Francesca Esposito, Ilaria Capozzo, Adelaide Riccardi…·Sofia Francia

The paper shows that dilncRNA, DROSHA, and DICER control DISC by recruiting BMI1 and promoting H2A-K119 ubiquitination at DNA double-strand breaks.

8 citations

humanDNA methylation

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Molecular BiologyCell Death and DifferentiationPeer-reviewedMay 28, 2025

DNA damage response defects induced by the formation of TDP-43 and mutant FUS cytoplasmic inclusions and their pharmacological rescue.

Stefania Modafferi, Stefania Farina, Francesca Esposito…·Sofia Francia

This study shows that TDP-43 and FUS cytoplasmic inclusions impair DNA damage response and repair, and that pharmacological stimulation of DDR can rescue these defects in ALS models.

14 citationstop 2%

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GeneticsbioRxivPreprintOct 27, 2020

TGS1 controls snRNA 3' end processing, prevents neurodegeneration and ameliorates SMN-dependent neurological phenotypes in vivo

Lü Chen, Caitlin M. Roake, Paolo Maccallini…·Grazia Daniela Raffa

This study shows TGS1 is essential for snRNA 3' end processing and its loss causes neurodegeneration, which can be mitigated by human TGS1 expression in model organisms.

2 citations

C. elegansDrosophila

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Cell BiologybioRxivPreprintFeb 7, 2018

DROSHA associates to DNA damage sites and is required for DNA repair

Matteo Cabrini, Marco Roncador, Alessandro Galbiati…·Sofia Francia

This study shows DROSHA localizes to DNA damage sites and is essential for NHEJ DNA repair.

DOI 10.1101/261289

humanDNA methylation

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