Author

Chi-Chang Weng

Chang Gung UniversityORCID 0000-0002-2989-3303Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Organism:rat· 1

Frequent Co-Authors

Robert H. MachiD· 2 shared Aladdin RiadiD· 1 shared Alexander M. Th. SchmitziD· 1 shared Anthony J. YoungiD· 1 shared Catherine HouiD· 1 shared Chenbo ZengiD· 1 shared Chia‐Ju HsiehiD· 1 shared Dinahlee Saturnino GuarinoiD· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersNeuroscience

Robert H. MachORCID

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2 papers

Recent·Most cited

A Small-molecule Antagonist Radiotracer for Positron Emission Tomography Imaging of the Mu Opioid Receptor.

Konstantinos Plakas, Chia‐Ju Hsieh, Dinahlee Saturnino Guarino, Catherine Hou, Wai‐Kit Chia, Anthony J. Young, Alexander M. Th. Schmitz, Yi-Pei Ho, Chi-Chang Weng, Hsiaoju S. Lee, Shihong Li, Thomas J. A. Graham, Robert H. Mach

This paper designs and characterizes non-agonist ligands for the mu opioid receptor, identifies a radiotracer [11C]1A for PET imaging, and demonstrates its brain uptake and receptor specificity in rhesus macaques.

bioRxiv · Oct 12, 2024 · PreprintNeuroscience

The Sigma-2 Receptor/TMEM97, PGRMC1, and LDL Receptor complex are responsible for the cellular uptake of Aβ42 and its protein aggregates

Aladdin Riad, Zsofia Lengyel‐Zhand, Chenbo Zeng, Chi-Chang Weng, Virginia M.‐Y. Lee, John Q. Trojanowski, Robert H. Mach

This study identifies the Sigma-2 receptor/TMEM97, PGRMC1, and LDLR complex as a pathway for Aβ42 uptake in neurons, both with and without apoE, suggesting it as a potential therapeutic target for Alzheimer's disease.

Molecular Neurobiology · Jun 23, 2020Peer-reviewedNeuroscience