Chungen Li

This study identifies a stress-lipid kinase axis in NEPC driven by PIKfyve, revealing a synthetic vulnerability between PIKfyve and FASN that can be exploited for therapeutic targeting.

This paper introduces epoxide- and aziridine-2-carboxamide electrophiles that covalently target RNA with stereoselectivity, demonstrating their application to RNA targets like r(CUG)exp repeats and FMN riboswitches.

This study designs a covalent small molecule targeting unpaired guanines in a riboswitch, showing it modulates riboswitch function in a cellular reporter system.