Author

Jingsong Shan

Scripps Research InstituteORCID 0000-0002-7252-6672Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Assay:metagenomics· 1 Assay:multiome· 1

Frequent Co-Authors

Matthew David DisneyiD· 3 shared Kisu SungiD· 2 shared Adeline Feri· 1 shared Álvaro Simba-LahuasiiD· 1 shared Amirhossein TaghaviiD· 1 shared Chungen LiiD· 1 shared David Georges Salthouse· 1 shared Henning Labuhn· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersBiochemistry

Matthew David DisneyORCID

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3 papers

Recent·Most cited

A Minimal Synthetic Cleavage Module Enables Selective Degradation of Pathogenic r(CUG) Repeats in Cells

Jingsong Shan, Sandra Kovachka, Kisu Sung, Matthew David Disney

This study develops a synthetic cleavage module that selectively degrades pathogenic r(CUG) repeats in cells, reducing DM1-associated pathology without DNA damage.

bioRxiv · Nov 6, 2026 · PreprintBiochemistry

A chemoinformatics-guided platform for efficient discovery of RNA-binding small molecules: Proof-of-concept for myotonic dystrophy type 1

Amirhossein Taghavi, Jingsong Shan, Xiyuan Yao, Patrick R. A. Zanon, Kisu Sung, Álvaro Simba-Lahuasi, Sylwia Gorlach, Henning Labuhn, David Georges Salthouse, Zhen Wang, Adeline Feri, Matthew David Disney

The paper develops a chemoinformatics platform to discover RNA-binding small molecules, identifying ligands for the r(CUG)exp RNA in DM1 with splicing rescue activity.

bioRxiv · May 13, 2026 · PreprintBioinformatics

Mechanistically Defined Epoxide- and Aziridine-2-carboxamide Electrophiles Enable Stereoselective Covalent RNA Modulation

Chungen Li, Xueyi Yang, Jingsong Shan, Kyle A. Dickerson, Noah A. Springer, Nikhil C. Munshi, Robert Batey, Matthew David Disney

This paper introduces epoxide- and aziridine-2-carboxamide electrophiles that covalently target RNA with stereoselectivity, demonstrating their application to RNA targets like r(CUG)exp repeats and FMN riboswitches.

bioRxiv · Jan 16, 2026 · PreprintBiochemistry