Author

Alessandra Silva Orfano

Yale UniversityORCID 0009-0007-8064-0778Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 1 Microbiology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Brian L. WeissiD· 2 shared Erick O. AwuocheiD· 2 shared Serap AksoyiD· 2 shared Amy Kristine BeiiD· 1 shared Anyirékun Fabrice SoméiD· 1 shared Aurélien VigneroniD· 1 shared Brian D. FoyiD· 1 shared Daniel J. BruzzeseiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersImmunology

Brian L. WeissORCID

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3 papers

Recent·Most cited

ImmunologyPLoS PathogensPeer-reviewedMay 4, 2026

PGRP-LA regulates peritrophic matrix synthesis and influences trypanosome infection outcomes in tsetse flies

Aurélien Vigneron, Brian L. Weiss, Yuebiao Feng…·Serap Aksoy

This study identifies PGRP-LA as a regulator of peritrophic matrix integrity in tsetse flies, influencing trypanosome infection outcomes by modulating gut barrier function rather than canonical immune signaling.

DOI 10.1371/journal.ppat.1013520

bulk RNA-seqexperimental assay

𝕏 PostBluesky

MicrobiologybioRxivPreprintNov 13, 2025

Anopheles mosquitoes exposed to long-acting antimalarials via drug-spiked bloodmeal absorb drug but do not suffer fitness costs

Morgan M. Goheen, Alessandra Silva Orfano, Sié Rodrigue Dah…·Sunil Parikh

This study shows Anopheles mosquitoes absorb long-acting antimalarials from bloodmeals but do not experience fitness costs, with drug detected in hemolymph and midguts.

1 citation

humanbulk RNA-seq

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Molecular BiologyPLoS PathogensPeer-reviewedJan 31, 2025

Spiroplasma endosymbiont reduction of host lipid synthesis and Stomoxyn-like peptide contribute to trypanosome resistance in the tsetse fly Glossina fuscipes

Erick O. Awuoche, Gretchen M. Smallenberger, Daniel J. Bruzzese…·Serap Aksoy

This study identifies Spiroplasma-induced lipid reduction and a Stomoxyn-like peptide as mechanisms contributing to trypanosome resistance in tsetse flies.

7 citationstop 5%

bulk RNA-seqstatistical model

𝕏 PostBluesky