PGRP-LA regulates peritrophic matrix synthesis and influences trypanosome infection outcomes in tsetse flies
Aurélien Vigneron, Brian L. Weiss, Yuebiao Feng, Jingwen Wang, Erick O. Awuoche, Hang Nguyen, Alessandra Silva Orfano, Liu Yang, Emre Aksoy, Serap Aksoy
This study identifies PGRP-LA as a regulator of peritrophic matrix integrity in tsetse flies, influencing trypanosome infection outcomes by modulating gut barrier function rather than canonical immune signaling.
PLoS Pathogens · May 4, 2026Peer-reviewedImmunology