Author

Chris D. St. Laurent

University of AlbertaORCID 0009-0007-9500-7406Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Immunology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Matthew Scott MacauleyiD· 3 shared Susmita SarkariD· 3 shared Edward N. SchmidtiD· 2 shared Jhon R. EnterinaiD· 2 shared Liany Luna-DulceyiD· 2 shared Madeline C. CrichtoniD· 2 shared Olivier JulieniD· 2 shared Sung-Yao LiniD· 2 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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3 shared papersImmunology

Matthew Scott MacauleyORCID

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3 papers

Recent·Most cited

ImmunologybioRxivPreprintMay 11, 2026

Siglec-G on B cells restrains the germinal center response by controlling T cell help during positive selection

Jhon R. Enterina, Sung-Yao Lin, Liany Luna-Dulcey…·Matthew Scott Macauley

This study identifies Siglec-G as a checkpoint receptor on B cells that limits germinal center (GC) response by modulating T cell help during positive selection.

DOI 10.64898/2026.05.06.723371

mouseexperimental assay

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BiochemistryScience AdvancesPeer-reviewedNov 12, 2025

An ultrasensitive and modular platform to detect Siglec ligands and control immune cell function

Zeinab Jame-Chenarboo, Edward N. Schmidt, Madeline C. Crichton…·Matthew Scott Macauley

The paper develops Siglec-liposomes to detect Siglec ligands and modulate immune cell function, showing they enhance T cell proliferation.

6 citations

humanexperimental assay

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NeurosciencebioRxivPreprintJul 4, 2023

Alzheimer's disease associated isoforms of human CD33 distinctively modulate microglial cell responses in 5XFAD mice

Ghazaleh Eskandari‐Sedighi, Madeline C. Crichton, Sameera Zia…·Matthew Scott Macauley

This study shows that human CD33 isoforms differentially affect microglial responses in Alzheimer's disease, with CD33m showing protective effects against amyloid-beta pathology.

3 citations

mousescRNA-seq

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