Susmita Sarkar

This study shows that knotted protein structures inhibit aggregation by limiting expanded states and suppressing liquid-liquid phase separation.

This study identifies Siglec-G as a checkpoint receptor on B cells that limits germinal center (GC) response by modulating T cell help during positive selection.

The paper develops Siglec-liposomes to detect Siglec ligands and modulate immune cell function, showing they enhance T cell proliferation.

This study identifies the Pel polysaccharide as a driver of autoaggregation in S. intermedius, linking it to biofilm formation and increased pathogenicity.

This study computationally simulates how microenvironmental factors influence Aβ40's liquid-liquid phase separation, revealing salt-driven reentrant condensation and temperature-dependent behavior.

This paper develops a phage-based liquid lectin array to detect subtle glycocalyx differences by displaying multivalent lectins on DNA-barcoded M13 phage.

This study shows ATP prevents protein aggregation and dissolves pre-formed aggregates, suggesting it could be a therapeutic agent for protein-aggregation diseases.

This study shows that human CD33 isoforms differentially affect microglial responses in Alzheimer's disease, with CD33m showing protective effects against amyloid-beta pathology.

This paper develops a DNA-encoded method to display multivalent proteins on phage and demonstrates its use to study in vivo clearance rates of L-asparaginase.