Author

Sameera Zia

University of AlbertaORCID 0000-0002-2956-0584Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:cell-cell communication· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:proteomics· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Jason R. PlemeliD· 2 shared Chris D. St. LaurentiD· 1 shared Dorothy P. SchaferiD· 1 shared Enrique ÁlvareziD· 1 shared Erik Gomez· 1 shared Gaurav Sidhu· 1 shared George S. MelchoriD· 1 shared Ghazaleh Eskandari‐SedighiiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersNeuroscience

Jason R. PlemelORCID

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2 papers

Recent·Most cited

Senescent-like microglia limit remyelination through the senescence associated secretory phenotype

Phillip S. Gross, Violeta Durán‐Laforet, Lana T. Ho, George S. Melchor, Sameera Zia, Zeeba Manavi, William E. Barclay, Sung Hyun Lee, Nataliia V. Shults, Sean Selva, Enrique Álvarez, Jason R. Plemel, Meng‐meng Fu, Dorothy P. Schafer, Jeffrey K. Huang

This study shows that senescent microglia impair remyelination in young mice but not aged mice, with CCL11 in SASP inhibiting oligodendrocyte maturation.

Nature Communications · Mar 7, 2025Peer-reviewedNeuroscience

Alzheimer's disease associated isoforms of human CD33 distinctively modulate microglial cell responses in 5XFAD mice

Ghazaleh Eskandari‐Sedighi, Madeline C. Crichton, Sameera Zia, Erik Gomez, Chris D. St. Laurent, Leonardo M. Cortez, Zain H. Patel, Gaurav Sidhu, Susmita Sarkar, Vivian Aghanya, Valerie L. Sim, Qiumin Tan, Olivier Julien, Jason R. Plemel, Matthew Scott Macauley

This study shows that human CD33 isoforms differentially affect microglial responses in Alzheimer's disease, with CD33m showing protective effects against amyloid-beta pathology.

bioRxiv · Jul 4, 2023 · PreprintNeuroscience